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                        CB-gene Reference is a trusted partner and supplier in the diagnostic testing industry.
                        The company attaches great importance to R&D and innovation. With our cell function modification technology, high-precision and flexible gene editing tool platform, we provide hundreds of standard reference materials for genetic diagnosis in various forms. We provide products and services for various drug research and development and genetic diagnosis institutions, and support the further understanding of gene functions of all species and the gene drivers of human diseases, as well as the development of personalized molecular, cellular and gene therapy.

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                        • 2021


                          [Target model + diagnostic quality control] Drug development and diagnosis of EGFR vIII

                          Epidermal growth factor receptor (EGFR/ErbB1/HER1) is a member of the tyrosine kinase receptor family, which also includes ErbB2/HER2/Neu, ErbB3/HER3 and ErbB4/HER4. All these receptors are transmembrane glycoproteins with molecular weights ranging from 170 to 185kDa. Generally, its activation involves ligand binding and subsequent receptor dimerization. The activation of EGF receptors can induce signals in the Ras/Raf/MAPK, PI3K/AKT, JAK/STAT or PLC/PKC pathways, and affect a variety of cellular processes, including proliferation, metabolism, apoptosis, cell survival or differentiation. The termination of the signal cascade occurs after the receptor is internalized, mainly clathrin-dependent endocytosis, leading to its entry into the early endosome. In addition, the receptor may be transported back to the cell membrane or degraded in late endosomes and lysosomes. learn more >>
                        • 2021


                          Gene Guardian: Tumor Suppressor Gene TP53

                          Mutations in the TP53 gene are common in a variety of cancer types. More than 50% of tumors will have mutations in this gene, which are usually related to disease progression, poor response to treatment, and poor prognosis. The protein P53 encoded by this gene has a molecular weight of about 53kDa, from which TP53 gets its name. learn more >>
                        • 2021


                          ctDNA liquid biopsy diagnostic standard

                          "Liquid Biopsy" (Liquid Biopsy) refers to a technology that uses human body fluid as a specimen source to detect and obtain tumor-related information. It is very important for early diagnosis, medication monitoring, and prognosis judgment of solid tumors. It has good compliance, easy access to specimens, and specificity. Good sex and other advantages. There will be a small amount of free circulating tumor cells (CTC) in the blood of cancer patients, and the necrotic cancer cells will also release a small amount of circulating tumor DNA (ctDNA) into the blood, so it can be detected from the primary tumor Or CTC and ctDNA released into the blood from the metastatic site to detect cancer. ctDNA (circulating tumor DNA), or circulating tumor DNA, refers to DNA fragments in the human blood that carry tumor-specific gene mutations, deletions, insertions, rearrangements, copy number variations, and methylation. learn more >>



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