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                        • 2021

                          12-28

                          [Target model + diagnostic quality control] Drug development and diagnosis of EGFR vIII

                          Epidermal growth factor receptor (EGFR/ErbB1/HER1) is a member of the tyrosine kinase receptor family, which also includes ErbB2/HER2/Neu, ErbB3/HER3 and ErbB4/HER4. All these receptors are transmembrane glycoproteins with molecular weights ranging from 170 to 185kDa. Generally, its activation involves ligand binding and subsequent receptor dimerization. The activation of EGF receptors can induce signals in the Ras/Raf/MAPK, PI3K/AKT, JAK/STAT or PLC/PKC pathways, and affect a variety of cellular processes, including proliferation, metabolism, apoptosis, cell survival or differentiation. The termination of the signal cascade occurs after the receptor is internalized, mainly clathrin-dependent endocytosis, leading to its entry into the early endosome. In addition, the receptor may be transported back to the cell membrane or degraded in late endosomes and lysosomes. learn more >>
                        • 2021

                          12-17

                          Gene Guardian: Tumor Suppressor Gene TP53

                          Mutations in the TP53 gene are common in a variety of cancer types. More than 50% of tumors will have mutations in this gene, which are usually related to disease progression, poor response to treatment, and poor prognosis. The protein P53 encoded by this gene has a molecular weight of about 53kDa, from which TP53 gets its name. learn more >>
                        • 2021

                          11-11

                          ctDNA liquid biopsy diagnostic standard

                          "Liquid Biopsy" (Liquid Biopsy) refers to a technology that uses human body fluid as a specimen source to detect and obtain tumor-related information. It is very important for early diagnosis, medication monitoring, and prognosis judgment of solid tumors. It has good compliance, easy access to specimens, and specificity. Good sex and other advantages. There will be a small amount of free circulating tumor cells (CTC) in the blood of cancer patients, and the necrotic cancer cells will also release a small amount of circulating tumor DNA (ctDNA) into the blood, so it can be detected from the primary tumor Or CTC and ctDNA released into the blood from the metastatic site to detect cancer. ctDNA (circulating tumor DNA), or circulating tumor DNA, refers to DNA fragments in the human blood that carry tumor-specific gene mutations, deletions, insertions, rearrangements, copy number variations, and methylation. learn more >>
                        • 2021

                          10-15

                          RNA-Fusion Cocktail is upgraded again, FFPE slide free trial

                          Gene fusion refers to linking the coding regions of two or more genes end to end and placing them under the control of the same set of regulatory sequences (including promoters, enhancers, and terminator, etc.) to form a chimeric gene. Gene fusions are usually caused by chromosomal rearrangements. Abnormal gene fusion events can cause malignant hematological diseases and tumors. Therefore, analyzing gene fusion phenomena will help to explore the pathogenesis and biomaker screening, which is of great clinical significance. learn more >>
                        • 2021

                          9-18

                          Tumor Fusion Gene Detection and Targeted Therapy

                          Gene fusion refers to the fusion of part or all of the sequences of two different genes due to a mechanism (such as genome mutation) to form a new gene. learn more >>
                        • 2021

                          8-27

                          [Target model + diagnostic quality control] Drug development and diagnosis of BTK C481S

                          Bruton's tyrosine kinase (BTK for short) is a tyrosine kinase encoded by the BTK gene. BTK contains 5 different protein interaction domains, including the amino-terminal pleckstrin homology (PH) domain, the proline-rich TEC homology (TH) domain, and the SRC homology (SH) domains SH2 and SH3. And the domain with kinase activity. learn more >>
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