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                        [New Product Online] FGFR Diagnostic Standard
                        2020-12-18 [1280]

                        Introduction to FGFR


                        FGFR, namely Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor), belongs to the family of receptor tyrosine kinases (RTKs) together with EGFR. In addition to EGFR and FGFR, the RTKs family also includes PDGFR (platelet-derived growth factor receptor) and VEGFR (vascular endothelial growth factor receptor).


                        The FGFR (Fibroblast Growth Factor Receptor) family mainly includes 4 subtypes, FGFR1, FGFR2, FGFR3 and FGFR4. Each subtype has an extracellular domain that binds to a ligand, a transmembrane domain, and an intracellular phosphorylated receptor. The structural characteristics of the district. The activation of FGFR signaling pathway is the key to several biological processes. Under normal physiological conditions, the FGF/FGF signaling pathway is involved in embryonic development (organogenesis and morphogenesis), tissue repair, angiogenesis, neuroendocrine and metabolic balance. In view of its complexity and key role in many important physiological processes, abnormal FGFR signal transduction has been found to be the inducement of tumor growth, promotion of angiogenesis, and resistance to anti-tumor therapy.


                        FGFR variant type


                        Wild-type FGFR without ligand stimulation is a normal FGFR structure. There are five common variants of FGFR:
                        (1) FGFR overexpression due to gene amplification;
                        (2) FGFR mutations (SNV and Indel) in the EC region (extracellular domain);
                        (3) FGFR mutations (SNV and Indel) in the TK region (kinase domain);
                        (4) FGFR fusion type I: gene fusion occurs before the TK region of FGFRs with the 5'end of another gene;
                        (5) FGFR Fusion Type II: The TK region of FGFRs is genetically fused with the 3'end of another gene.



                        FGFR clinical significance


                        Clinically, FGFR mutations can cause cancer. Related examples include:
                        (1) FGFR1 amplification is related to squamous non-small cell lung cancer and breast cancer;
                        (2) FGFR2 mutation is related to endometrial cancer and gastric cancer;
                        (3) FGFR2 fusion is related to liver cancer;
                        (4) FGFR3 fusion is related to myeloma;
                        (5) FGFR3 mutation is related to bladder cancer;
                        (6) FGFR4 amplification/mutation has been seen in patients with rhabdomyosarcoma.


                        FGFR companion diagnostic method


                        Before finding suitable patients for FGFR inhibitor treatment, patients need to be tested and screened for FGFR gene mutations. The current FDA-approved diagnostic kits include the following FGFR:
                        (1) Therascreen® FGFR RGQ RT-PCR Kit
                        (2) Caris Molecular Intelligence Profle
                        (3) FoundationOne CDx
                        (4) Guardant360


                        Cobioer Gene can provide diagnostic standards for multiple types of FGFR mutations, which can provide solutions for the verification of diagnostic methods for pharmaceutical companies and diagnostic companies when looking for suitable patients to ensure the detection limit, sensitivity and stability of the diagnostic method.


                        Product Data




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