Home > products > Mutation > Gene editing > AI-Edigene? FGFR3 p.S249C Reference Standard Plus
                        AI-Edigene? FGFR3 p.S249C Reference Standard Plus
                        FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).

                        Model:CBP10553

                        Update time:[2021-08-10]
                        Parameter
                        CBP10553
                        Format Genomic DNA
                        Description FGFR3, fibroblast growth factor receptor 3, is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways (PMID: 22508544). Altered function of FGFR3 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544) and mutations and fusions are commonly observed in bladder cancer (PMID: 30975452, PMID: 23175443).
                           
                        Technical Data 
                        DNA Change: c.746C>G
                        AA Change p.S249C
                        Mutation type Substitution - Missense
                        Zygosity Heterozygous
                        Allelic Frequency 50.00%
                        Transcript NM_000142.5
                        Buffer: Tris-EDTA
                           
                        Product Information 
                        Intended Use Research Use Only
                        Unit Size 1ug
                        Concentration Download for COA
                        Purity Download for COA
                        DNA electrophoresis Download for COA
                        Sanger sequencing
                        Storage -20℃
                        Expiry 36 months from the date of manufacture

                         

                         

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